In advanced organic synthesis, rhodium(II) acetate dimer (Rh ₂ (OAc) ₄ ， CAS: 15956-28- 2 ) has emerged as a strategic catalyst for CH activation, ylide formation, and metalcarbene/nitrene transfer reactions, owing to its unique dirhodium structure and axial coordination capability. With exceptional stereocontrol and functional group tolerance, it is driving precision manufacturing in pharmaceuticals and advanced materials. Below are cuttingedge breakthroughs in its three core applications for 2025: 1. Directed CH Activation: Precision Modification of Drug Molecules As an efficient CH activation catalyst, Rh ₂ (OAc) ₄ enables atomeconomical functionalization through rhodiumcarbene intermediates: Anticancer drug optimization: Catalyzes direct amination of aromatic CH bonds in PD1/PDL1 inhibitors with >99% ee Natural product modification: Hydroxylation at C13H bond of paclitaxel side chain (91% yield vs. ≤ 65% conventional)...